A specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter; at 5 μM

Fumitremorgin C – 1 mg

Brand:
Cayman
CAS:
118974-02-0
Storage:
4
UN-No:
De Minimis - 3462 / 6.1

Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3.2 colon carcinoma cells.{20755} Fumitremorgin C reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1).{20754,20756}  

 

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SKU: 11030 - 1 mg Category:

Description

A specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter; at 5 μM, significantly potentiates the toxicity of chemotherapeutic drugs in colon carcinoma cells; reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1)

Formal name: 1,2,3,5aS,6,11,12S,14aS-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1”,2”:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,14-dione

Synonyms:  Tryptoquivaline

Molecular weight: 379.5

CAS: 118974-02-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Multidrug Resistance||Research Area|Toxicology|Drug Metabolism

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