An inhibitor of Nampt and NF-κB pathway activity; potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells lines; inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer xenografts in nude mice at 20-50 mg/kg/day

CHS-828 – 50 mg

Brand:
Cayman
CAS:
200484-11-3
Storage:
-20
UN-No:
Non-Hazardous - /

CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.{20745,20747} CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo.{20744} In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.{20744}  

 

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SKU: 11021 - 50 mg Category:

Description

An inhibitor of Nampt and NF-κB pathway activity; potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells lines; inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer xenografts in nude mice at 20-50 mg/kg/day

Formal name: N-[6-(4-chlorophenoxy)hexyl]-N’-cyano-N”-4-pyridinyl-guanidine

Synonyms:  GMX 1778

Molecular weight: 371.9

CAS: 200484-11-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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