A minor alkaloid produced in plants of the Solanaceae family

(R,S)-Anatabine – 50 mg

Brand:
Cayman
CAS:
2743-90-0
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco.{20193} The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used.{20195,20196} (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats.{20194} Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 µg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.{20197}  

 

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SKU: 11001 - 50 mg Category:

Description

A minor alkaloid produced in plants of the Solanaceae family, including tobacco; detection in urine is used as an indicator of tobacco use; diminishes Aβ production, reduces the transcription and protein levels of β-secretase, and dose dependently inhibits NF-κB activation

Formal name: 1,2,3,6-tetrahydro-2,3′-bipyridine

Synonyms: 

Molecular weight: 160.2

CAS: 2743-90-0

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Proteolysis||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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