A natural demethoxy derivative of curcumin; activates macrophage phagocytosis and

Bisdemethoxycurcumin – 5 mg

Brand:
Cayman
CAS:
33171-05-0
Storage:
-20
UN-No:
Non-Hazardous - /

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC).{19781,19788,19791} More stable than curcumin in physiological media, BDMC suppresses proliferation in cancer cells.{19787,19792} It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.{19784,19789}  

 

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SKU: 10960 - 5 mg Category:

Description

A natural demethoxy derivative of curcumin; activates macrophage phagocytosis and, with 1α,25-dihydroxy vitamin D3, stimulates amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC); suppresses proliferation in cancer cells; down-regulates p300 and inhibits LPS-induced iNOS expression

Formal name: 1,7-bis(4-hydroxyphenyl)-1E,6E-heptadiene-3,5-dione

Synonyms:  BDMC

Molecular weight: 308.3

CAS: 33171-05-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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