A selective PPARα agonist; exhibits EC50 values of 50 and 55 µM for mouse and human PPARα

Clofibrate – 1 g

Brand:
Cayman
CAS:
637-07-0
Storage:
-20
UN-No:
De Minimis - 3082 / 9

Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).{10670} In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.  

 

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SKU: 10956 - 1 g Category:

Description

A selective PPARα agonist; exhibits EC50 values of 50 and 55 µM for mouse and human PPARα, respectively; inactive at PPARδ at concentrations up to 100 µM,

Formal name: 2-(4-chlorophenoxy)-2-methyl-propanoic acid, ethyl ester

Synonyms:  ICI 28257|NSC 79389

Molecular weight: 242.7

CAS: 637-07-0

Purity: ≥98%

Formulation: A neat oil

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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