An analog of calcitriol that

22-Oxacalcitriol – 5 mg

Brand:
Cayman
CAS:
103909-75-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis.{22231,22230} First reported to avoid hypercalcemia, an undesirable side effect of calcitriol, prolonged treatment with 22-oxalcalcitriol can be calcemic in humans.{22231,22230} Analogs of calcitriol, including 22-oxacalcitriol, inhibit human keratinocyte proliferation while inducing differentiation and is beneficial in treating psoriasis.{22227,22226} 22-Oxacalcitriol also blocks the proliferation while inducing differentiation and apoptosis of certain tumor cells.{22229}  

 

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SKU: 10794 - 5 mg Category:

Description

An analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis; inhibits human keratinocyte proliferation and is beneficial in treating psoriasis; blocks the proliferation while inducing differentiation and apoptosis of certain tumor cells

Formal name: 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol

Synonyms:  Maxacalcitrol

Molecular weight: 418.6

CAS: 103909-75-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor

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