A flavonoid with diverse biological activities; reduces tumor growth in an NCI-H1975 NSCLC mouse xenograft model at 1 and 5 mg/kg; inhibits hepatic steatosis and prevents increases in hepatic TBARS

Isoliquiritigenin – 1 mg

Brand:
Cayman
CAS:
961-29-5
Storage:
-20
UN-No:
Non-Hazardous - /

Isoliquiritigenin is a flavonoid that is found in Glycyrrhizae species and has diverse biological activities including anticancer, anti-steatotic, antioxidant, anti-inflammatory, gastroprotective, and estrogenic properties.{43332,43333,19281,19284,29598} It reduces tumor growth in an NCI-H1975 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at doses of 1 and 5 mg/kg.{43332} Isoliquiritigenin (10 mg/kg per day) inhibits hepatic steatosis, as indicated by reduced hepatic fat and triglyceride accumulation, and increases in hepatic thiobarbituric acid-reactive substances (TBARS), inducible nitric oxide synthase (iNOS), and COX-2 levels in mice fed a high-fat diet.{19284} It also inhibits LPS-induced increases in IL-1β and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 μM, respectively).{43333} Isoliquiritigenin (5 and 10 mg/kg) reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats.{19281} It is an estrogen receptor α (ERα) and ERβ agonist (IC50s = 16 and 7.8 μM, respectively) and induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 μM).{29598} Isoliquiritigenin is also a histamine H2 receptor and liver X receptor α (LXRα) antagonist.{19281,19284}  

 

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SKU: 10739 - 1 mg Category:

Description

A flavonoid with diverse biological activities; reduces tumor growth in an NCI-H1975 NSCLC mouse xenograft model at 1 and 5 mg/kg; inhibits hepatic steatosis and prevents increases in hepatic TBARS, iNOS, and COX-2 levels in mice fed a high-fat diet at 10 mg/kg per day; inhibits LPS-induced increases in IL-1β and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 μM, respectively); reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats at 5 and 10 mg/kg; an ERα and ERβ agonist (IC50s = 16 and 7.8 μM, respectively); induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 μM); a histamine H2 receptor and LXRα antagonist

Formal name: 1-(2E,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

Synonyms:  GU 17|ILQ|ISL

Molecular weight: 256.3

CAS: 961-29-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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