A racemic mixture of (+)-WIN 55

(±)-WIN 55,212 (mesylate) – 50 mg

Brand:
Cayman
CAS:
137795-17-6
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-WIN 55,212 is a racemic mixture of the cannabinoid (CB) receptor 1 (CB1) and CB2 agonist (+)-WIN 55,212-2 (Item No. 10009023) and the CB2 neutral antagonist (−)-WIN 55,212-3 (Item No. 12022).{13290} It inhibits electrically induced contractions in mouse vas deferens preparations (IC50 = 0.006 µM) and reduces prostaglandin (PG) synthesis by 35% in mouse brain microsomes when used at a concentration of 30 µM.{13045} (±)-WIN 55,212 decreases acetylcholine-induced writhing in mice with an ED50 value of 0.25 mg/kg. It induces hypolocomotion, analgesia, hypothermia, and catalepsy in mice (ED50s = 1.09, 0.5, 3.01 and 6.8 mg/kg, respectively).{56218}  

 

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SKU: 10736 - 50 mg Category:

Description

A racemic mixture of (+)-WIN 55,212-2 and (−)-WIN 55,212-3; inhibits electrically induced contractions in mouse vas deferens preparations (IC50 = 0.006 µM) and reduces PG synthesis by 35% in mouse brain microsomes at 30 µM; decreases acetylcholine-induced writhing in mice (ED50 = 0.25 mg/kg); induces hypolocomotion, analgesia, hypothermia, and catalepsy in mice (ED50s = 1.09, 0.5, 3.01 and 6.8 mg/kg, respectively)

Formal name: [2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone, methanesulfonate

Synonyms: 

Molecular weight: 522.6

CAS: 137795-17-6

Purity: ≥98%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Pain Research

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