Description
An anthelmintic mitochondrial uncoupler; inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy; induces mitochondrial uncoupling, activates AMPK, and increases lipid peroxidation in vitro at 1 µM; prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice at 125 mg/kg per day; inhibits proliferation and colony formation of DU145 prostate cancer cells (IC50s = 0.7 and 0.1 µM, respectively)
Formal name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide
Synonyms: NSC 178296
Molecular weight: 327.1
CAS: 50-65-7
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Nutrient Sensing||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors
