Inhibits recombinant human and mouse sEH (IC50s both = 0.4 nM) and demonstrates a 1

CAY10640 – 1 mg

Brand:
Cayman
CAS:
1208549-68-1
Storage:
-20
UN-No:
Non-Hazardous - /

Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM.{18630} CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.{18630}  

 

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Description

Inhibits recombinant human and mouse sEH (IC50s both = 0.4 nM) and demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model

Formal name: N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy)phenyl]-urea

Synonyms:  sEHi|Soluble Epoxide Hydrolase Inhibitor

Molecular weight: 371.4

CAS: 1208549-68-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation

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