FLLL32 – 25 mg

Brand:
Cayman
CAS:
1226895-15-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

FLLL32 is a cell-permeable analog of curcumin (Item No. 81025) that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50 = ~5 µM).{33676,18692} It blocks signaling from IFN-α or IL-6 through JAK2/STAT3 and induces apoptosis in several types of cancer cells.{33676,18692} FLLL32 does not interfere with IFN-γ-induced STAT1 signaling and does not adversely affect the function or viability of immune cells.{33676} Through its effects on JAK2/STAT3 signaling, FLLL32 enhances the chemo- and radiosensitivity of cancer cells.{18692,33675,33677}  

 

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SKU: 10638 - 25 mg Category:

Description

,An inhibitor of JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50 = ~5 µM); blocks signaling from IFN-α or IL-6 through JAK2/STAT3 and induces apoptosis in several types of cancer cells

Formal name: (2E,2’E)-1,1′-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one

Synonyms:  JAK2 Inhibitor X

Molecular weight: 464.6

CAS: 1226895-15-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cell Biology|Cell Signaling|JAK Signaling

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