An agonist of GPR199 that is effective both in isolated cells and in vivo; increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 μM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg)

AS-1269574 – 10 mg

Brand:
Cayman
CAS:
330981-72-1
Storage:
-20
UN-No:
De Minimis - 1170 / 3

GPR119, a glucose-dependent insulinotropic receptor, is a Gs protein-coupled receptor that is expressed in pancreas β-cells and intestinal L-cells.{14046} Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine and oleoyl ethanolamide increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion.{14046,18880} AS-1269574 is an agonist of GPR119 that is effective both in isolated cells and in vivo.{18583} It increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 μM) and glucose-stimulated insulin secretion in mice (100 mg/kg).{18583}  

 

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SKU: 10626 - 10 mg Category:

Description

An agonist of GPR199 that is effective both in isolated cells and in vivo; increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 μM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg)

Formal name: 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-ethanol

Synonyms: 

Molecular weight: 308.2

CAS: 330981-72-1

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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