A potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM

Olaparib – 100 mg

Brand:
Cayman
CAS:
763113-22-0
Storage:
-20
UN-No:
Non-Hazardous - /

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER).{20677} Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER.{22577} Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM).{24275} It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.{24275,20554,20549,20553}  

 

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SKU: 10621 - 100 mg Category:

Description

A potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM); can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death

Formal name: 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone

Synonyms:  AZD 2281|Ku-0059436

Molecular weight: 434.5

CAS: 763113-22-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|PARP

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