An orally bioavailable

PLX4032 – 5 mg

Brand:
Cayman
CAS:
918504-65-1
Storage:
-20
UN-No:
Non-Hazardous - /

PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively).{27947} It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the proliferation of B-RafV600E transformed cancer cells.{27947} PLX4032 is effective against the growth of tumors bearing the B-Raf V600E mutation.{18549,18645,27944,27852}  

 

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SKU: 10618 - 5 mg Category:

Description

An orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively); inhibits cell proliferation in a variety of cell lines expressing B-RafV600E and is effective against the growth of tumors bearing the B-RafV600E mutation

Formal name: N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide

Synonyms:  RG-7204|Ro 51-85426|Vemurafenib

Molecular weight: 489.9

CAS: 918504-65-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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