An inhibitor of Tph1 that blocks the biosynthesis of gut-derived serotonin; prevents the development of and fully rescues

LP-533401 – 25 mg

Brand:
Cayman
CAS:
945976-43-2
Storage:
-20
UN-No:
Non-Hazardous - /

LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that blocks the biosynthesis of gut-derived serotonin, completely inhibiting serotonin production in Tph1-expressing cells at a dose of 1 µM.{32686} It prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized and aged mice.{32686,32684} LP-533401 has also been used to elucidate the role of gut-derived serotonin in pulmonary hypertension and leukemia in mice.{32683,32685}  

 

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SKU: 10492 - 25 mg Category:

Description

An inhibitor of Tph1 that blocks the biosynthesis of gut-derived serotonin; prevents the development of and fully rescues, in a dose-dependent manner, osteoporosis in ovariectomized and aged

Formal name: 4-[2-amino-6-[2,2,2-trifluoro-1-(3′-fluoro[1,1′-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]-L-phenylalanine

Synonyms: 

Molecular weight: 526.5

CAS: 945976-43-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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