A prodrug of the potent

Candesartan Cilexetil – 1 g

Brand:
Cayman
CAS:
145040-37-5
Storage:
-20
UN-No:
Non-Hazardous - /

Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.{18424} Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} In addition to its anti-hypertensive properties, blockade of AT1 receptors with 10 mg/kg/day candesartan cilexetil in cold-restraint stressed SHR rats prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus, suggesting a therapeutic role in stress-related disorders.{18423}  

 

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SKU: 10489 - 1 g Category:

Description

A prodrug of the potent, long-acting, and selective AT1 receptor antagonist, candesartan; 4-16 mg/day effectively reduces diastolic blood pressure and has proved useful in the treatment of hypertension and diabetes

Formal name: 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

Synonyms:  TCV-116

Molecular weight: 610.7

CAS: 145040-37-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience

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