A prodrug of 5-fluorouracil; cytotoxic only at high concentrations in Scaber

Capecitabine – 500 mg

Brand:
Cayman
CAS:
154361-50-9
Storage:
-20
UN-No:
Non-Hazardous - /

Capecitabine is a prodrug of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).  

 

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SKU: 10487 - 500 mg Category:

Description

A prodrug of 5-fluorouracil; cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively); inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM)

Formal name: 5′-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine

Synonyms:  Ro 09-1978

Molecular weight: 359.4

CAS: 154361-50-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair

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