An epoxide derivative of DHA that is generated by the action of CYP450 epoxygenases; naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids; a substrate of soluble epoxide hydrolase (KM = 15 µM)

(±)7(8)-EpDPA – 50 µg

Brand:
Cayman
CAS:
895127-66-9
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Docosahexaenoic acid (DHA, Item No. 90310) is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases.{29511} It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids.{29249,29509} (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting vasodilation, inhibiting angiogenesis, and decreasing inflammatory and neuropathic pain.{29509,26641,29512,29510} (±)7(8)-EpDPA is a substrate of soluble epoxide hydrolase (KM = 15 µM), which converts it to the corresponding diol.{29509}  

 

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SKU: 10465 - 50 µg Category:

Description

An epoxide derivative of DHA that is generated by the action of CYP450 epoxygenases; naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids; a substrate of soluble epoxide hydrolase (KM = 15 µM)

Formal name: (±)-(4Z)-6-[3-(2Z,5Z,8Z,11Z)-2,5,8,11-tetradecatetraen-1-yl-2-oxiranyl]-4-hexenoic acid

Synonyms:  (±)7,8-EDP|(±)7,8-EpDPE|(±)7,8-epoxy Docosapentaenoic Acid|(±)7,8-epoxy DPA

Molecular weight: 344.5

CAS: 895127-66-9

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Neuroscience|Pain Research

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