A DHA epoxygenase metabolite found in rat brain and spinal cord that acts as a preferred substrate for sEH (Km = 3.2 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays

(±)13(14)-EpDPA – 100 µg

Brand:
Cayman
CAS:
895127-64-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid (DHA; Item No. 90310) epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 µM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models.{29509} (±)13(14)-EpDPA and other epoxy metabolites of DHA are also reported to potently inhibit angiogenesis and tumor growth in in vitro assays.{26641}  

 

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SKU: 10464 - 100 µg Category:

Description

A DHA epoxygenase metabolite found in rat brain and spinal cord that acts as a preferred substrate for sEH (Km = 3.2 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays

Formal name: (±)-(4Z,7Z,10Z)-12-[3-(2Z,5Z)-2,5-octadien-1-yl-2-oxiranyl]-4,7,10-dodecatrienoic acid

Synonyms:  (±)13,14-EDP|(±)13,14-EpDPE|(±)13,14-epoxy Docosapentaenoic Acid|(±)13,14-epoxy DPA

Molecular weight: 344.5

CAS: 895127-64-7

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Neuroscience|Pain Research

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