A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM

24(R)-hydroxy Cholesterol – 10 mg

Brand:
Cayman
CAS:
27460-26-0
Storage:
-20
UN-No:
Non-Hazardous - /

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis.{15406} 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM, respectively) compared to the natural isomer (EC50 = 4 and 3 μM, respectively).{15406,25539}  

 

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SKU: 10217 - 10 mg Category:

Description

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM, respectively) compared to the natural isomer (EC50 = 4 and 3 μM, respectively)

Formal name: cholest-5-ene-3β,24R-diol

Synonyms:  24-Epicerebrosterol

Molecular weight: 402.7

CAS: 27460-26-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience

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