An organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM

IDFP – 10 mg

Brand:
Cayman
CAS:
615250-02-7
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) hydrolyze 2-AG and AEA, respectively, thus terminating their biological function. IDFP is an organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively.{16841} At 10 mg/kg, IDFP elevates brain levels of 2-AG and AEA more than 10-fold, and decreases levels of arachidonic acid by a similar magnitude.{16841}  

 

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SKU: 10215 - 10 mg Category:

Description

An organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively; at 10 mg/kg, it elevates brain levels of 2-AG and AEA more than 10-fold and decreases levels of arachidonic acid by a similar magnitude

Formal name: P-dodecyl-phosphonofluoridic acid, 1-methylethyl ester

Synonyms:  Isopropyl Dodecylfluorophosphonate

Molecular weight: 294.4

CAS: 615250-02-7

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Glycerolipids|Lipases||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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