A lipid peroxidation product; actively modifies histidine and lysine residues on proteins and causes protein cross-linking

4-oxo-2-Nonenal – 5 mg

Brand:
Cayman
CAS:
103560-62-9
Storage:
-80
UN-No:
De Minimis - 1231 / 3

4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-oxo-2-Nonenal also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278}  

 

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SKU: 10185 - 5 mg Category:

Description

A lipid peroxidation product; actively modifies histidine and lysine residues on proteins and causes protein cross-linking

Formal name: 4-oxo-2E-nonenal

Synonyms:  4-ONE

Molecular weight: 154.2

CAS: 103560-62-9

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Fatty Alcohols/Aldehydes||Research Area|Cancer|DNA Damage and Repair||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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