A glucosylceramide synthase inhibitor; inhibits glucosylceramide synthase by 50% at a 5 µM in an enzyme assay; the active component of racemic DL-threo-PDMP; inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells at 25 µM; inhibits B4GALT6 and prevents lactosylceramide synthesis; inhibits ganglioside biosynthesis

(+)-D-threo-PDMP (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
139889-62-6
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Item No. 62595).{11392} (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase.{11391,11341} It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 μM in an enzyme assay.{11341} (+)-D-threo-PDMP is the active component of racemic DL-threo-PDMP (Item No. 10005276). In vitro, (+)-D-threo-PDMP inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells when used at a concentration of 25 µM and inhibits cell binding to laminin and collagen when used at concentrations of 10 and 25 µM.{36024} It also inhibits β-1,4-galactosyltransferase 6 (B4GALT6) and prevents lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} (+)-D-threo-PDMP inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice.{36881} [Matreya, LLC. Catalog No. 1756]  

 

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Description

A glucosylceramide synthase inhibitor; inhibits glucosylceramide synthase by 50% at a 5 µM in an enzyme assay; the active component of racemic DL-threo-PDMP; inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells at 25 µM; inhibits B4GALT6 and prevents lactosylceramide synthesis; inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice

Formal name: N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride

Synonyms:  D-PDMP

Molecular weight: 427

CAS: 139889-62-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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