Ubiquitous lipid species generated following PLA2 hydrolysis of phosphatidylcholine; increases the production of ROS and decreases SOD and eNOS protein levels and phosphorylation of ERK1/2 in HUVECs at 125 µM; potentiates the secretion of IL-6

1-Palmitoyl-2-hydroxy-sn-glycero-3-PC – 500 mg

Brand:
Cayman
CAS:
17364-16-8
Storage:
-20
UN-No:
Non-Hazardous - /

1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine.{11139} It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 µM.{42919} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 µM.{42920} It increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 µM.{42921} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.{11693}  

 

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SKU: 10172 - 500 mg Category:

Description

Ubiquitous lipid species generated following PLA2 hydrolysis of phosphatidylcholine; increases the production of ROS and decreases SOD and eNOS protein levels and phosphorylation of ERK1/2 in HUVECs at 125 µM; potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages at 0.3-1.0 µM; increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood at 10 µM; enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis at 10 mg/kg.

Formal name: 1-hexadecanoyl-sn-glycerol-3-phosphorylcholine

Synonyms:  16:0/0:0-PC|1-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine|1-Hexadecanoyl-sn-glycero-3-Phosphocholine|1-Palmitoyl-sn-glycero-3-Phosphocholine|PC(16:0/0:0)

Molecular weight: 495.6

CAS: 17364-16-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Glycerophospholipids||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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