An inhibitor of alkaline ceramidase (Ki = 2-13 µM; IC50 = 1-5 µM); selective for alkaline ceramidase over acid ceramidase (IC50 = >500 µM) as well as CAPP at 0/G1 phase

D-erythro-MAPP – 10 mg

Brand:
Cayman
CAS:
143492-38-0
Storage:
-20
UN-No:
Non-Hazardous - /

D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 µM; IC50 = 1-5 µM).{3672} It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 µM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 µM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.  

 

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SKU: 10165 - 10 mg Category:

Description

An inhibitor of alkaline ceramidase (Ki = 2-13 µM; IC50 = 1-5 µM); selective for alkaline ceramidase over acid ceramidase (IC50 = >500 µM) as well as CAPP at 0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells ,

Formal name: N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2E,4E,6R-trimethyl-2,4-decadienamide

Synonyms:  (1S,2R-D-erythro-2-N-myristoylamino)-1-phenyl-1-propanol

Molecular weight: 361.6

CAS: 143492-38-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer|Cell Cycle|G1||Research Area|Lipid Biochemistry|Sphingolipids

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