A potent and selective inhibitor of FAAH (IC50 = 4.6 nM in brain membranes and 0.5 nM in intact neurons

URB597 – 50 mg

Brand:
Cayman
CAS:
546141-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

URB597 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme that hydrolyzes anandamide (AEA; Item No. 90050) and other simple esters and amides with long unsaturated acyl chains (IC50 = 4.6 nM and 0.5 nM in brain membranes and intact neurons, respectively).{10666,3310} URB597 exhibits both antinociceptive and anxiolytic effects in vivo without evoking other symptoms associated with cannabinoid-like compounds. This antinociceptive effect is similar to those observed in FAAH(-/-) mice.{9576}  

 

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SKU: 10046 - 50 mg Category:

Description

A potent and selective inhibitor of FAAH (IC50 = 4.6 nM in brain membranes and 0.5 nM in intact neurons, respectively); exhibits both antinociceptive and anxiolytic effects in vivo without evoking other symptoms associated with CB-like compounds

Formal name: (3′-(aminocarbonyl)[1,1′-biphenyl]-3-yl)-cyclohexylcarbamate

Synonyms: 

Molecular weight: 338.4

CAS: 546141-08-6

Purity: >98%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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