A 3-furyl arachidonoyl analog that acts as a potent and selective reuptake inhibitor of AEA (IC50 = 0.8 µM) but has low affinity for FAAH (IC50 = 30 µM); potentiates the biological effects of AEA when co-administered in rats

UCM707 – 25 mg

Brand:
Cayman
CAS:
390824-20-1
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

Numerous analogs of arachidonoyl ethanolamide (AEA, anandamide) potentiate its biological activity.{1134} This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.{10647} One of the more potent and selective reuptake inhibitors is UCM707, a 3-furyl arachidonoyl analog. UCM707 has an IC50 of 0.8 µM for the inhibition of tritiated AEA uptake into human U937 cells but has low affinity for FAAH, exhibiting an IC50 value of 30 µM.{11303} UCM707 also potentiates the biological effects of AEA when co-administered in rats.{10504}  

 

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Description

A 3-furyl arachidonoyl analog that acts as a potent and selective reuptake inhibitor of AEA (IC50 = 0.8 µM) but has low affinity for FAAH (IC50 = 30 µM); potentiates the biological effects of AEA when co-administered in rats

Formal name: N-(3-furanylmethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Synonyms: 

Molecular weight: 383.6

CAS: 390824-20-1

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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