A potent ghrelin receptor antagonist (IC50 = 1.1 nM) that inhibits hexarelin-stimulated food intake by as much as 98% in rats at 80 µg/kg; does not affect growth hormone release when tested in infant rats

JMV3002 – 1 mg

Brand:
Cayman
CAS:
925239-03-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro.{15848} At 80 µg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats.{15848} JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 µg/kg.{15848}  

 

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SKU: 10012699 - 1 mg Category:

Description

A potent ghrelin receptor antagonist (IC50 = 1.1 nM) that inhibits hexarelin-stimulated food intake by as much as 98% in rats at 80 µg/kg; does not affect growth hormone release when tested in infant rats

Formal name: N-[(1R)-1-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenyylethyl)-4H-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]-2-pyridinecarboxamide

Synonyms: 

Molecular weight: 586.7

CAS: 925239-03-8

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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