An Hsp90 inhibitor (IC50 = 30 nM in a fluorescence polarization assay); selective for Hsp90 over a panel of kinases (IC50s = >20 µM); inhibits the proliferation of HCT116

Benzisoxazole Hsp90 Inhibitor – 5 mg

Brand:
Cayman
CAS:
1012788-65-6
Storage:
-20
UN-No:
Non-Hazardous - /

Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay).{15810} It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.  

 

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SKU: 10012694 - 5 mg Category:

Description

An Hsp90 inhibitor (IC50 = 30 nM in a fluorescence polarization assay); selective for Hsp90 over a panel of kinases (IC50s = >20 µM); inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively); induces degradation of HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively (IC50 = 0.33 µM for both)

Formal name: 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-1,3-benzenediol

Synonyms:  BHI

Molecular weight: 389.8

CAS: 1012788-65-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones

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