A derivative of fosmidomycin that has antimalarial activity; inhibits DOXP reductoisomerase in vitro in a dose-dependent manner; exhibits in vitro antimalarial activity against three P. falciparum strains (IC50s = 170

FR900098 (sodium salt) – 5 mg

Brand:
Cayman
CAS:
73226-73-0
Storage:
-20
UN-No:
Non-Hazardous - /

FR900098 is a derivative of fosmidomycin (Item No. 16000) that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively).{26495} FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner.{26495} FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.  

 

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SKU: 10012681 - 5 mg Category:

Description

A derivative of fosmidomycin that has antimalarial activity; inhibits DOXP reductoisomerase in vitro in a dose-dependent manner; exhibits in vitro antimalarial activity against three P. falciparum strains (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 strains, respectively); FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice,

Formal name: P-[3-(acetylhydroxyamino)propyl]-phosphonic acid, monosodium salt

Synonyms: 

Molecular weight: 219.1

CAS: 73226-73-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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