An inhibitor of the ERAD pathway

Eeyarestatin 1 – 10 mg

Brand:
Cayman
CAS:
412960-54-4
Storage:
-20
UN-No:
Non-Hazardous - /

Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM.{15691} It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3.{27313,27314} Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.{27315}  

 

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SKU: 10012609 - 10 mg Category:

Description

An inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM; associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3; interferes with both retrograde and anterograde trafficking of proteins,

Formal name: 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl] hydroxyamino]-5,5-dimethyl-2-oxo-1- imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

Synonyms: 

Molecular weight: 630.4

CAS: 412960-54-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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