An organic polysulfide compound found in garlic that acts as an H2S donor; reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM); suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation.

Diallyl Trisulfide – 250 mg

Brand:
Cayman
CAS:
2050-87-5
Storage:
-20
UN-No:
Excepted Quantity - 1993 / 3

Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor.{16966} It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM){16967} and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM).{16969} DATS suppresses the growth of PC-3 xenografts in vivo in mice{16968} and induces vascular smooth muscle relaxation.{16966} Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.{16970,16971}  

 

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SKU: 10012577 - 250 mg Category:

Description

An organic polysulfide compound found in garlic that acts as an H2S donor; reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM); suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation.

Formal name: di-2-propen-1-yl trisulfide

Synonyms:  DATS|NSC 651936

Molecular weight: 178.3

CAS: 2050-87-5

Purity: ≥95%

Formulation: A solution in acetone

Product Type|Biochemicals|Ox Stress Reagents|Hydrogen Sulfide Donors||Research Area|Cancer||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|H2S

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