A potent

CAY10583 – 10 mg

Brand:
Cayman
CAS:
862891-27-8
Storage:
-20
UN-No:
Non-Hazardous - /

Leukotriene B4 (LTB4) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis. Two G protein-coupled receptors, BLT1 and BLT2 mediate the actions of LTB4. CAY10583 is a potent, selective full agonist for BLT2 with an EC50 value of 20 nM.{15624} It does not displace [3H]-leukotriene B4 (LTB4) binding to BLT1 at concentrations >1 µM and activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM).{15624} CAY10583 dose dependently increases intracellular calcium stores and induces ERK phosphorylation in Chinese hamster ovary (CHO) cells expressing BLT2 with no effect on CHO cells expressing BLT1.{15624}  

 

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SKU: 10012424 - 10 mg Category:

Description

A potent, selective full agonist for BLT2 with an EC50 value of 20 nM; activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM); dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO cells expressing BLT2 with no effect on CHO cells expressing BLT1

Formal name: 4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid

Synonyms: 

Molecular weight: 387.5

CAS: 862891-27-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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