A potent and selective histamine H4 receptor antagonist

JNJ-7777120 – 50 mg

Brand:
Cayman
CAS:
459168-41-3
Storage:
-20
UN-No:
Non-Hazardous - /

JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors.{18909} Its Ki values for the histamine H1-3 receptors exceed 1 μM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters.{18909} JNJ-777120 inhibits mast cell chemotaxis induced by 10 μM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.).{18909} It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation.{18910, 18911}  

 

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SKU: 10011925 - 50 mg Category:

Description

A potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors; inhibits mast cell chemotaxis induced by 10 μM histamine (IC50 = 40 nM), reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.), and impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation

Formal name: (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone

Synonyms: 

Molecular weight: 277.8

CAS: 459168-41-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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