Inhibitor of NF-κB activation that blocks the phosphorylation of IKK and IκB (IC50 ~ 40 μM); dose dependently inhibits the expression and secretion of IL-6

Avenanthramide-C methyl ester – 1 mg

Brand:
Cayman
CAS:
955382-52-2
Storage:
-20
UN-No:
Non-Hazardous - /

Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM).{15451} Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells. {15451}  

 

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SKU: 10011336 - 1 mg Category:

Description

Inhibitor of NF-κB activation that blocks the phosphorylation of IKK and IκB (IC50 ~ 40 μM); dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

Formal name: 2-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]amino]5-hydroxy-benzoic acid, methyl ester

Synonyms: 

Molecular weight: 329.3

CAS: 955382-52-2

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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