A benzimidazole analog that selectively inhibits IKKε with an IC50 value of 40 nM and is essentially inactive at IKKα and IKKβ

CAY10576 – 10 mg

Brand:
Cayman
CAS:
862812-98-4
Storage:
-20
UN-No:
Non-Hazardous - /

The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKKα and IKKβ phosphorylation. IKKε, a homolog of IKKα and IKKβ, can also activate NF-κB. IKKε is expressed predominantly in immune cells, and is thought to play a role in the immune response. CAY10576 is a benzimidazole analog that selectively inhibits IKKε with an IC50 value of 40 nM and is essentially inactive at IKKα and IKKβ.{16237}  

 

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SKU: 10011249 - 10 mg Category:

Description

A benzimidazole analog that selectively inhibits IKKε with an IC50 value of 40 nM and is essentially inactive at IKKα and IKKβ

Formal name: 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile

Synonyms: 

Molecular weight: 469.5

CAS: 862812-98-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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