A selective inhibitor of ABHD6 (IC50 = 70 nM); increases Ucp1 expression and the OCR in differentiated 3T3-L1 mouse adipocytes at 10 µM; increases the expression of Ucp1

WWL70 – 25 mg

Brand:
Cayman
CAS:
947669-91-2
Storage:
-20
UN-No:
Non-Hazardous - /

WWL70 is an inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 70 nM).{15297} It increases the expression of the adipose browning-related gene Ucp1 in differentiated 3T3-L1 mouse adipocytes and increases the oxygen consumption rate (OCR), an effect that can be blocked by the PPARα antagonist GW 6471 (Item No. 11697), when used at a concentration of 10 µM.{53349} WWL70 (10 mg/kg per day) also increases the expression of the adipose browning-related genes Ucp1, Prdm16, Tmem26, and Tbx1 in visceral adipose tissue in mice fed a high-fat diet. WWL70 reduces adipose tissue mass and prevents glucose-intolerance and increases in body weight in mice fed a high-fat diet but does not reduce hepatic triacylglycerol levels.{53350} It increases brain levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) and decreases the severity of experimental autoimmune encephalomyelitis (EAE) in wild-type, but not cannabinoid (CB) receptor 2 (CB2) knockout, mice when administered at a dose of 10 mg/kg per day starting at disease onset.{53351}  

 

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Description

A selective inhibitor of ABHD6 (IC50 = 70 nM); increases Ucp1 expression and the OCR in differentiated 3T3-L1 mouse adipocytes at 10 µM; increases the expression of Ucp1, Prdm16, Tmem26, and Tbx1 in visceral adipose tissue in mice fed a high-fat diet at 10 mg/kg per day; reduces adipose tissue mass and prevents glucose-intolerance and increases in body weight in mice fed a high-fat diet; increases brain levels of 2-AG and decreases EAE severity in wild-type, but not CB2 receptor knockout, mice at 10 mg/kg per day starting at disease onset

Formal name: N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-carbamic acid, 4′-(aminocarbonyl)[1,1′-biphenyl]-4-yl ester

Synonyms: 

Molecular weight: 437.5

CAS: 947669-91-2

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Thermogenesis||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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