A cell-permeable selective PDE4 inhibitor

(±)-Rolipram – 5 mg

Brand:
Cayman
CAS:
61413-54-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Type 4 cyclic nucleotide phosphodiesterases (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. (±)-Rolipram is a cell-permeable selective PDE4 inhibitor. Since PDE4 is abundant in leukocytes, (±)-rolipram inhibits inflammation by suppressing leukocyte function, inhibiting C5a-stimulated LTC4 synthesis in eosinophils (IC50 = 200 nM),{16522} and lipopolysaccharide-induced TNF synthesis in monocytes (IC50 = 360 nM).{16523} (±)-Rolipram also enhances neuronal survival,{16524} has antipsychotic effects in mice,{16525} and suppresses bone loss in ovariectomized rats.{16526}  

 

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SKU: 10011132 - 5 mg Category:

Description

A cell-permeable selective PDE4 inhibitor

Formal name: 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Synonyms:  SB 95952|ZK 62711

Molecular weight: 275.3

CAS: 61413-54-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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