A stimulator of sGC

BAY 41-8543 – 1 mg

Brand:
Cayman
CAS:
256498-66-5
Storage:
-20
UN-No:
Non-Hazardous - /

Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY 41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold.{17529} Surprisingly, NO donors synergize with BAY 41-8543 in stimulating recombinant sGC.{17529} BAY 41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations.{17529} In vivo, BAY 41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis.{17530} Inhalation of microparticles containing BAY 41-8543 increases pulmonary vasodilation without changing mean arterial pressure,{17531} suggesting that agonists of sGC may be efficacious in treating pulmonary hypertension.  

 

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SKU: 10011131 - 1 mg Category:

Description

A stimulator of sGC, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold; in vitro, relaxes vessels and inhibits platelet aggregation at nM concentrations; in vivo, decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis

Formal name: 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine

Synonyms: 

Molecular weight: 420.4

CAS: 256498-66-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Cyclases||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Cell Signaling|cGMP Signaling||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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