A carotenoid with diverse biological activities; reduces hyperglycemia-induced mitochondrial DNA damage and production of ROS and promotes mitochondrial biogenesis in ARPE-19 cells at 10 µM; increases NO production and decreases serum levels of endothelin-1 in a rat model of hyperhomocysteinemia at 20 mg/kg; dietary administration decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis; reduces infarct size and cardiac MDA

Lutein – 25 mg

Brand:
Cayman
CAS:
127-40-2
Storage:
-20
UN-No:
Non-Hazardous - /

Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities.{56228,56230,56229,56231} It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 µM.{56228} Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 (Item No. 24127) in a rat model of hyperhomocysteinemia.{56230} Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol (Item No. 15592).{56229} It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.{56231}  

 

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SKU: 10010811 - 25 mg Category:

Description

A carotenoid with diverse biological activities; reduces hyperglycemia-induced mitochondrial DNA damage and production of ROS and promotes mitochondrial biogenesis in ARPE-19 cells at 10 µM; increases NO production and decreases serum levels of endothelin-1 in a rat model of hyperhomocysteinemia at 20 mg/kg; dietary administration decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis; reduces infarct size and cardiac MDA, LDH, and troponin T levels, and increases cardiac CAT, SOD, HO-1, and Nrf2 in a rat model of isoproterenol-induced heart failure; high dietary intake is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans

Formal name: (6’R)-β,ε-carotene-3R,3’R-diol

Synonyms:  E 161b|Xanthophyll

Molecular weight: 568.9

CAS: 127-40-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Carotenoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Ophthalmology||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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