A selective inhibitor of PDGF receptor kinase with an IC50 value of20 µM in human bone marrow; inhibits the EGF receptor with an IC50 value of 820 µM

AG-370 – 25 mg

Brand:
Cayman
CAS:
134036-53-6
Storage:
-20
UN-No:
Non-Hazardous - /

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues.{14963} AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 µM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 µM).{16600,850,16601}  

 

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SKU: 10010568 - 25 mg Category:

Description

A selective inhibitor of PDGF receptor kinase with an IC50 value of20 µM in human bone marrow; inhibits the EGF receptor with an IC50 value of 820 µM

Formal name: 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile

Synonyms:  NSC 651712

Molecular weight: 259.3

CAS: 134036-53-6

Purity: ≥95% (cis/trans mixture)

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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