A potent and selective inhibitor of reticulocyte 15-LO-1

PD 146176 – 5 mg

Brand:
Cayman
CAS:
4079-26-9
Storage:
-20
UN-No:
Non-Hazardous - /

PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1.{16748} It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells.{16748,16747,16745} PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.{16746} In addition, it lacks significant non-specific antioxidant properties.{16747}  

 

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SKU: 10010518 - 5 mg Category:

Description

A potent and selective inhibitor of reticulocyte 15-LO-1

Formal name: 6,11-dihydro-[1]benzothiopyrano[4,3-b]indole

Synonyms:  NSC 168807

Molecular weight: 237.3

CAS: 4079-26-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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