An irreversible

Tranylcypromine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
1986-47-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tranylcypromine is an irreversible, mechanism-based inhibitor of lysine-specific demethylase 1 (LSD1; IC50 = 20.7 µM in a cell-free assay).{15036} It also irreversibly inhibits monoamine oxidase A (MAO-A) and MAO-B with IC50 values of 2.3 and 0.95 µM, respectively. Tranylcypromine inhibits nucleosomal demethylation of histone H3 lysine 4 (H3K4; IC50 = 13122) to promote the differentiation of keratinocytes into induced pluripotent stem cells (iPSCs) when transduced with the transcription factors Oct4 and Klf4.{49327} It also decreases proliferation of neural progenitors in the hippocampal dentate gyrus in adult mice when administered at a dose of 10 mg/kg for ten days.{49328} Tranylcypromine (0.5-10 mg/kg) decreases the time juvenile rats spend immobile in the forced swim test, indicating antidepressant-liked activity.{49329} Formulations containing tranylcypromine have been used in the treatment of treatment-resistant major depressive disorder.  

 

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SKU: 10010494 - 100 mg Category:

Description

An irreversible, mechanism-based inhibitor of LSD1 (IC50 = 20.7 µM); irreversibly inhibits MAO-A and MAO-B (IC50s = 2.3 and 0.95 µM, respectively); PCPA inhibits nucleosomal demethylation of H3K4 (IC50 = <2 µM); induces EpiSCs to convert to more undifferentiated state but requires inhibitors of ALK5, MEK, FGFR, and GSK3 for full conversion to pluripotent mESCs; decreases proliferation of neural progenitors in the hippocampal dentate gyrus in adult mice at 10 mg/kg for ten days; decreases the time juvenile rats spend immobile in the forced swim test at 0.4-10 mg/kg

Formal name: (1R,2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride

Synonyms:  trans-2-Phenylcyclopropylamine|2-PCPA

Molecular weight: 169.7

CAS: 1986-47-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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