A potent and reversible inhibitor of JNK-3 (IC50 = 0.11 μM)

SP 600125 – 25 mg

Brand:
Cayman
CAS:
129-56-6
Storage:
-20
UN-No:
Non-Hazardous - /

The three isoforms of c-Jun N-terminal kinase (JNK) are members of the MAP kinase superfamily that induce the expression of immediate-early genes in response to specific stress and inflammatory signals. Through these actions, the JNK enzymes modulate cell proliferation, apoptosis, differentiation, and autophagy. SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 μM.{16589} It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells.{16589} SP 600125 also prevents apoptosis in many cell types, including B-cells,{16588} and inhibits autophagy in HeLa cells.{16590}  

 

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SKU: 10010466 - 25 mg Category:

Description

A potent and reversible inhibitor of JNK-3 (IC50 = 0.11 μM)

Formal name: anthra[1,9-cd]pyrazol-6(2H)-one

Synonyms:  1PMV|NSC 75890|Pyrazolanthrone

Molecular weight: 220.2

CAS: 129-56-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JNK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JNK Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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