Initiates glycogen synthesis in hepatocytes by causing inactivation of phosphorylase a and activation of glycogen synthase a (maximal effects with ~20 µM Itu); potent inhibitor of ERK2 (Ki = 525 nM)

5-Iodotubercidin – 5 mg

Brand:
Cayman
CAS:
24386-93-4
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

5-Iodotubercidin (Itu) is an adenosine derivative that initiates glycogen synthesis in hepatocytes by causing inactivation of phosphorylase α and activation of glycogen synthase α (maximal effects with ~20 µM Itu).{15220} Itu can inhibit a broad range of PKs including PKA (IC50 = 5-10 µM), phosphorylase kinase (IC50 = 5-10 µM), casein kinase I (IC50 = 0.4 µM) and II (IC50 = 10.9 µM), and PKC (IC50 = 0.4 µM), which appears to account for its glycogenic action.{15083} Itu is also a highly potent inhibitor of ERK2 (Ki = 525 nM), a protein kinase with important roles in cell proliferation.{15221} Mediated by the inhibition of acetyl-CoA carboxylase, Itu increases fatty acid oxidation activity of the liver at the expense of lipogenesis.{15219}  

 

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SKU: 10010375 - 5 mg Category:

Description

Initiates glycogen synthesis in hepatocytes by causing inactivation of phosphorylase a and activation of glycogen synthase a (maximal effects with ~20 µM Itu); potent inhibitor of ERK2 (Ki = 525 nM)

Formal name: 5-iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms:  Itu|NSC 113939

Molecular weight: 392.2

CAS: 24386-93-4

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Kinase Inhibitors|CK1||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Activators||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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