A potent CB2 receptor agonist with ED50 values of 91 and 63 nM in rat and human

GW 842166X – 10 mg

Brand:
Cayman
CAS:
666260-75-9
Storage:
-20
UN-No:
Non-Hazardous - /

The peripheral cannabinoid (CB2) receptor is a G protein-coupled receptor (GPCR) that is localized predominantly in immune cells, monocytes, macrophages, and in several peripheral organs and binds the active component of cannabis, Δ9-tetrahydrocannabinol, as well as anandamide, an endogenous CB receptor ligand.{15353} GW 842166X is a peripheral cannabinoid (CB2) receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively.{14965} When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg.{14965}  

 

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SKU: 10010372 - 10 mg Category:

Description

A potent CB2 receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively

Formal name: 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide

Synonyms: 

Molecular weight: 449.3

CAS: 666260-75-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Pain Research

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