A potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4

CJ-023423 – 1 mg

Brand:
Cayman
CAS:
415903-37-6
Storage:
-20
UN-No:
Non-Hazardous - /

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.{16619,16772,16773} CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively).{14958,26175} It inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection of PGE2.{14958} CJ-023423 reduces acute and chronic inflammatory pain in different mouse models.{14958}  

 

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SKU: 10010355 - 1 mg Category:

Description

A potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively); inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection of PGE2

Formal name: N-[[2,4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenylethylamino]carbonyl]-4-methyl-benzenesulfonamide

Synonyms:  Grapiprant|RQ-00000007

Molecular weight: 491.6

CAS: 415903-37-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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