A prodrug of lovastatin hydroxy acid; a potent and competitive inhibitor of HMG-CoA reductase (Kis = 1.4 and 0.6 nM for lovastatin and lovastatin hydroxy acid

Lovastatin – 50 mg

Brand:
Cayman
CAS:
75330-75-5
Storage:
-20
UN-No:
Non-Hazardous - /

Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus.{15081} It is a prodrug of its more potent metabolite, lovastatin hydroxy acid (Item No. 10010339). Both competitively inhibit HMG-CoA reductase with Ki values of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form, respectively.{15251} Lovastatin (8 mg/kg/day) reduces plasma cholesterol in dogs by 29% over a three week period. It also suppresses TNF-induced NF-κB activation (IC50 ~ 15 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.{15363} Formulations containing lovastatin were the first HMG-CoA reductase inhibitors to be used in the treatment of hypercholesterolemia.  

 

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SKU: 10010338 - 50 mg Category:

Description

A prodrug of lovastatin hydroxy acid; a potent and competitive inhibitor of HMG-CoA reductase (Kis = 1.4 and 0.6 nM for lovastatin and lovastatin hydroxy acid, respectively); reduces plasma cholesterol by 29% in dogs over a period of three weeks at a dose of 8 mg/kg/day; suppresses TNF-induced NF-κB activation (IC50 ~ 15 µM),

Formal name: 2S-methyl-butanoic acid, 1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester

Synonyms: 

Molecular weight: 404.5

CAS: 75330-75-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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