An inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme); binds to the HMG-CoA binding site; inhibits human CYP2C9 (IC50 = 100 nM); inhibits increases in serum cholesterol

Fluvastatin – 10 mg

Brand:
Cayman
CAS:
93957-54-1
Storage:
-20
UN-No:
Non-Hazardous - /

Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme) that binds to the HMG-CoA binding site.{15309,15312} It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM).{37698} Fluvastatin (2 mg/kg per day) inhibits increases in serum cholesterol, triglycerides, phospholipids, and thiobarbituric acid-reactive substances (TBARS) levels, as well as vascular angiotensin converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet.{37699} It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day.{37700} Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.  

 

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SKU: 10010334 - 10 mg Category:

Description

An inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme); binds to the HMG-CoA binding site; inhibits human CYP2C9 (IC50 = 100 nM); inhibits increases in serum cholesterol, triglycerides, phospholipids, and TBARS levels, as well as vascular ACE activity in rabbits fed a high-cholesterol diet at 2 mg/kg; increases survival in a mouse model of myocardial infarction at 10 mg/kg per day

Formal name: 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid

Synonyms: 

Molecular weight: 411.5

CAS: 93957-54-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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