A selective inhibitor of EGF receptor-associated tyrosine kinase (IC50 = 11 nM); used to differentiate rat mesenchymal stem cells

Lavendustin A – 5 mg

Brand:
Cayman
CAS:
125697-92-9
Storage:
-20
UN-No:
Non-Hazardous - /

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate.{16076,32582} It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 µM).{32582} It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.{28437,16078,25113}  

 

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SKU: 10010268 - 5 mg Category:

Description

A selective inhibitor of EGF receptor-associated tyrosine kinase (IC50 = 11 nM); used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis

Formal name: 5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid

Synonyms:  NSC 678027|RG-14355

Molecular weight: 381.4

CAS: 125697-92-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Neuroscience

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